Indian Scientists on Dec 8th revealed the world the completely sequenced Human genome of a 52 year old healthly Indian.Dr. Sridhar Sivasubbu and Dr. Vinod Scaria, the scientists who responsible for this milestone are from the Institute of Genomics and Integrative Biology, New Delhi a CSIR Laboratory. With this achievement India is now in the league of select few countries like United States, China, Canada, United Kingdom, and Korea who have demonstrated the capability to sequence and assemble complete human genomes. More news in detail......
Addressing a press conference Union Minister Shri. Prithviraj Chavan said that this feat is unique in the sense that it has been achieved by a team of very young scientists. CSIR has been endeavoring to nucleate such teams in different niche technological areas as per the directive of Hon’ble Dr. Manmohan Singh, President, CSIR and Prime Minister of India. This initiative is paying off.
Elaborating the details of research on Human Genome , the Minister said that the first Human Genome Sequence in the world was a result of the International Human Genome Project comprising scientists from United States, United Kingdom, France, Germany, Japan and China. The Project formally started in 1990 and the sequencing was completed in 2003. This spectacular feat at that time was hailed equivalent to the man landing on the moon. India could not be a part of this large initiative as in the early nineties it lacked the necessary resources. CSIR could achieve this by adopting new technologies and by effectively integrating complex computational tools with high throughput analytical capabilities.
While the first Human Genome Sequence effort took more than a decade spending over a billion US dollars, CSIR scientists at IGIB finished the complete sequencing and assembly in much shorter time comparable with similar recent effort the world over. By using next generation technologies and skills, they successfully bridged the technological gap that existed a decade ago.
Sh. S.K. Brahmchari, DG, CSIR informed that the Human Genome has 3.1 billion base pairs. The team at IGIB generated over 51 Gigabases of data using next generation sequencing technology, resulting in over 13x coverage of the Human Genome. This next-generation sequencing technology enables massively parallel sequencing of millions of genomic fragments of 76 base pairs, which are then mapped back to the reference genome. This humongous exercise was made possible with the CSIR supercomputing facility at IGIB.
The sequencing of the first Human Genome in India in conjunction with Indian Genome variation programme(http://www.igvdb.res.in/) opens newer vistas for low cost affordable healthcare and predictive medicine in future for the masses. This also opens up newer possibilities in disease diagnostics, treatment and sustaining low-cost drugs in the market.
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1 comment:
proud of u dr vinod n team....
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